<em>In silico</em> pharmacokinetic and toxicological study of Flavone analogues

Flavone analogs are natural compounds of the flavonoid class that have a wide range biological activities. The present study aimed to predict, with aid in silico methodologies, oral bioavailability and pharmacokinetic toxicological analyzes for three flavone analogues (apigenin, chrysin luteonlin). revealed good availability, favorable parameters. Virtual Screening performed predict all did not violate Lipinski's Rule. high intestinal absorption, do cross blood-brain barrier, permeable by Caco-2 cells inhibit P-glycoprotein. ADME showed enzymes cytochrome P450 complex (CYP4501A2, CYP4502C9, CYP4502C19, CYP4503A4) only CYP4502D6 enzyme. Toxicology indicated show toxicity AMES Test carcinogenic. Apigenin low toxicity, while luteolin has moderate toxicity.